Prolonged prevention of squamous cell carcinoma of the skin by regular sunscreen use.
نویسندگان
چکیده
Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants for a further 8 years to evaluate possible latency of preventive effect on BCCs and SCCs. After prolonged follow-up, BCC tumor rates tended to decrease but not significantly in people formerly randomized to daily sunscreen use compared with those not applying sunscreen daily. By contrast, corresponding SCC tumor rates were significantly decreased by almost 40% during the entire follow-up period (rate ratio, 0.62; 95% confidence interval, 0.38-0.99). Regular application of sunscreen has prolonged preventive effects on SCC but with no clear benefit in reducing BCC.
منابع مشابه
Short Communication Prolonged Prevention of Squamous Cell Carcinoma of the Skin by Regular Sunscreen Use
Half of all cancers in the United States are skin cancers. We have previously shown in a 4.5-year randomized controlled trial in an Australian community that squamous cell carcinomas (SCC) but not basal cell carcinomas (BCC) can be prevented by regular sunscreen application to the head, neck, hands, and forearms. Since cessation of the trial, we have followed participants for a further 8 years ...
متن کاملSunscreen use for skin cancer prevention.
Evidence-Based Answer Daily sunscreen use reduces the incidence of squamous cell carcinoma but not the incidence of basal cell carcinoma. (Strength of Recommendation [SOR]: B, based on a single randomized controlled trial with less than 13 years of follow-up). It is unclear whether there are longer-term effects. There is no consistent, conclusive evidence that sunscreen use prevents melanoma. (...
متن کاملCancers in Australia attributable to exposure to solar ultraviolet radiation and prevented by regular sunscreen use
OBJECTIVES To estimate the proportion and numbers of cancers occurring in Australia attributable to solar ultraviolet radiation (UVR) and the proportion and numbers prevented by regular sun protection factor (SPF) 15+ sunscreen use. METHODS We estimated the population attributable fraction (PAF) and numbers of melanomas and keratinocyte cancers (i.e. basal cell carcinomas and squamous cell ca...
متن کاملPoint: sunscreen use is a safe and effective approach to skin cancer prevention.
Sunscreens prevent sunburn. They have also been proven to be somewhat effective in preventing squamous cell carcinoma (1). However, both the most numerous (basal cell carcinoma) and the most deadly (melanoma) skin cancers have little evidence for efficacy of sunscreens. Therefore, using sunscreens as an approach to skin cancer prevention for basal cell carcinoma or cutaneous malignant melanoma ...
متن کاملCounterpoint: sunscreen use is a safe and effective approach to skin cancer prevention.
Sunscreens prevent sunburn. They have also been proven to be somewhat effective in preventing squamous cell carcinoma (1). However, both the most numerous (basal cell carcinoma) and the most deadly (melanoma) skin cancers have little evidence for efficacy of sunscreens. Therefore, using sunscreens as an approach to skin cancer prevention for basal cell carcinoma or cutaneous malignant melanoma ...
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 15 12 شماره
صفحات -
تاریخ انتشار 2006